"Furazolidone" for intestinal infections, as well as a role in gynecology and urology

"Furazolidone" is an antimicrobial agent with experience. The first active substance of the same name was synthesized in the 50s of the XX century by Soviet scientists S.A. Hiller and R.Yu. Kalnberg. A distinctive feature of "Furazolidone" is that bacteria are not able to develop resistance to it, therefore it is effective against various microbes resistant to antibiotics and sulfonamides.

Synonyms of “Furazolidone”: “Diafuron”, “Furoxon”, “Neftein”, “Neokolen”, “Nifulidon”, “Optazol”. Analogs by effect: "Nifuroxazide", "Enterofuril", "Imipenem", "Ciprofloxacin". Release form: tablets of 0.05 g in a package of 20 pieces and granules of 50 g in glass containers with a volume of 150 ml.

Positive effects of the drug

Furazolin, furalizidone, furazidol, furazodolin, furanidazole, furodolizole, furadonizole are the same thing and does even one of these drugs help in gynecology? The substance furazolidone is a derivative of nitrofuran. It is able to suppress the reproduction and growth of gram-negative bacteria, as well as unicellular microorganisms Trichomonas and Giardia. It has a bacteriostatic effect, which is achieved due to the following mechanisms:

• inhibits the enzyme systems of microorganisms;
• violates the mechanism of endogenous respiration;
• inhibits intracellular protein synthesis.

Pyogenic microorganisms and anaerobic infection to Furazolidone are relatively stable.

The composition of the tablet includes excipients that must be considered when prescribing a medicine:

• potato starch;
• lactose monohydrate;
• silica;
• calcium stearate.

Absorption from the digestive system occurs quickly, "Furazolidone" is able to penetrate the central nervous system. Bioavailability is 30%, the maximum concentration is reached after about three hours. The therapeutic effect is observed for six hours. The main metabolism occurs in the liver. 65% of the drug is excreted by the kidneys, the rest - with bile through the intestines. This ensures its effect in intestinal infections. With renal failure, its elimination slows down, the drug accumulates in the blood.

Fields of application

How to take the drug? The main indications for the use of "Furazolidone" are intestinal infections, accompanied by diarrhea, vomiting. Sometimes they use Furazolidone in gynecology and urology.

• Foodborne Toxic Infection. This is a group of infectious diseases that arose as a result of human poisoning by seeded products of microbial flora. The main symptoms are caused by bacterial toxins. These are nausea, vomiting, frequent loose stools, fever and dehydration. It is important to consult a doctor on time to distinguish between food and rotavirus infection.If the cause of the disease is a virus, then Furazolidone will not help.
• Dysentery. This infectious disease is characterized by damage to the large intestine with the development of dysenteric colitis. The disease begins with an increase in body temperature, later frequent (up to 20 times a day) stool, pains and rumbling in the abdomen join. With the development of the disease, the nature of defecation changes; instead of feces, a small amount of mucus with blood is released, the so-called "rectal spit".
• Paratyphus. The cause of this disease is Salmonella bacteria. Another name is salmonellosis. It differs from other intestinal infections by the presence of a roseola rash, which affects the patient, starting from the fourth day of the disease.
• Trichomoniasis. Sexually transmitted infection. It affects the genitourinary system of women and men. It appears in the form of colpitis, vaginitis, endometritis, salpingo-oophoritisurethritis.
• Giardiasis. The cause of this disease is the simplest microorganisms - giardia. They parasitize in the small intestine and may not manifest themselves for a long time. The clinical picture occurs due to damage to the gastrointestinal tract (chronic enteritis) or the gall bladder (cholangitis, cholecystitis). Persistent headaches and increased fatigue may disturb the patient. This is often the only symptom.
• Cystitis. It is used if inflammation of the bladder is caused by sensitive flora. But you can not combine "Furazolidone" and antibiotics - tetracyclines and aminoglycosides. This can lead to anemia.
• Stomach ulcer. "Furazolidone" is not a drug of choice, but recently, cases of resistance of Helicobacter pylori to antibiotics have become more frequent. Therefore, therapy using this nitrofuran derivative is allowed as a reserve.
• Pancreatitis. With inflammation of the pancreas, furazolidone is used in combination with other antimicrobials.
• Remediation of organs. To prepare for surgery for hemorrhoids, with chronic pharyngitis, gastritis, proctitis.
• Burns and wound infections. It is applied topically in the form of a solution or wet dressings.

In what cases can not be used

Contraindications to "Furazolidone" include serious diseases and conditions:

• allergy- individual intolerance to the drug and its components;
• impaired renal function - problems with the removal of furazolidone;
• glucose-6-phosphate dehydrogenase deficiency - metabolic disorder of the drug;
• liver pathology - it is impossible to dispose of the medicine;
• pregnancy and lactation - negative effect on the fetus;
• children under eight - use at an early age is undesirable due to imperfection of the metabolism.

Instructions for use "Furazolidone": the intensity of therapy depending on the pathology

Dosages for treatment with "Furazolidone" depend on the pathology. It is convenient to use the table to determine the dose and frequency of administration.

Table - Dosage of “Furazolidone”

How is tolerated

Among all derivatives of nitrofuran "Furazolidone" stands out as the easiest tolerance, however, it has various side effects. Sometimes observed:

• appetite suppression;
• dyspeptic phenomena;
• headache;
• allergic reactions.

Perhaps the development of a hypersensitivity reaction with a decrease in blood pressure, fever and pain in the joints. Against the background of prolonged ingestion, microflora is disturbed with the development of dysbiosis.

Since Furazolidone inhibits the enzyme monoamine oxidase, certain preventive measures should be taken when using it: exclude foods rich in tyramine (cheese, cream, beer, wine, chocolate, smoked meats, seafood) from the diet. Combination treatment with antidepressants - MAO inhibitors, sympathomimetics should be extremely careful, since there is a high risk of a hypertensive crisis.

The maximum dose of "Furazolidone" for adults inside:

• single - 0.2 g;
• daily allowance - 0.8 g.

In case of an overdose, patients note manifestations of neurotoxic effects. Perhaps the development of toxic hepatitis, problems from the hematopoietic system.

Over the long history of the use of Furazolidone, many reviews of doctors have accumulated about this drug. Both positive and negative, associated with the toxic effect of the drug. Given its relative cheapness and affordability, the use of Furazolidone for adults and older children is widespread. However, self-medication with this drug is unacceptable, extremely dangerous.

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