The content of the article
There is such a connection. And her instruction to the drug mentions her. During clinical trials of Glucofage, it was found that obese patients lose weight by taking therapeutic doses of the drug. It is not surprising that the drug rushed to test on themselves opponents of diets who want to build.
The composition and effect of the product
The drug "Glucophage" contains the active substance - metformin. It refers to biguanides with antihyperglycemic activity, that is, capable of lowering blood sugar. The sugar-lowering effect is based on the fact that the medicine glucophage helps affects the body in three ways.
- Effect on the liver. The liver is involved in the processing of sugars entering the bloodstream. She is responsible for the process of splitting sugar reserves with the release of glucose molecules into the blood and the synthesis of glucose from non-sugar substances. Glucophage inhibits these processes, which affects the amount of free glucose circulating in the patient’s bloodstream.
- Intestinal effects. "Glucophage" delays the glucose received from food in the intestinal lumen, which ensures its excretion from the body along with feces.
- Effect on the muscles. Glucophage increases glucose uptake by peripheral tissues, and more specifically, by muscles, which lowers sugar levels and prevents the deposition of fat stores.
About the "pitfalls"
From the listed characteristics of the drug, it can be concluded that Glucophage is an amazing help while observing a diet and the real dream of “lazy” losing weight. Why, then, nutritionists do not recommend everyone to get rid of extra pounds with the help of the drug "Glyukofazh"? The answer to this question lies in the processes that accompany the main pharmacological actions of the drug. We list them.
- He will not free from diet. Glucophage blocks the absorption of glucose in the intestine by acting on certain receptors and slowing down the breakdown of polysaccharides into simple molecules. Hence, increased gas formation and a complex of dyspeptic side effects if the patient is abusing carbohydrate food. The main condition for treatment with Glucofage is a low-carb diet.
- Possible harm. Pharmacological drugs are created for sick people. In this case, patients suffer from resistance of the body's cells to their own insulin. Glucophage increases the sensitivity of cells to the hormone, allowing it to participate in natural metabolic processes.A medical increase in the sensitivity of cells to insulin in a healthy person can adversely affect the patient's well-being after discontinuation of the drug.
- Muscle reaction. Increased transportation of glucose to muscle tissue requires the consumption of large amounts of sugar by these tissues. In the absence of physical activity, an increase in intracellular glycogen synthesis will lead to the deposition of fat reserves. Only not with the liver, but directly with muscle tissue. So, "Glucophage" does not eliminate the need for physical exertion. At the same time, excessive physical activity is prohibited when taking the drug due to the increased risk of the accumulation of lactic acid and ketone bodies. Finding a balance without the help of a specialist is very difficult.
The question is for those who are losing weight: why should a healthy person put himself at risk of the negative effects of the drug and possible troubles in the future in order to lose weight in the previous mode? If you carefully consider the instructions from the manufacturer, you can find information that the same clinical studies that confirmed weight loss with obesity in one part of the patients noted the complete safety of weight in the other part of the participants.
Instructions for use and dosage of "Glucophage"
For those who consulted with a doctor and came to the conclusion that it is necessary to supplement the diet with the use of the Glucofage drug, the question of a difficult choice will arise directly in the pharmacy - the drug has several dosages and dosage forms. What kind of remedy to buy? The comparative characteristics of the release forms presented in the table will answer the question.
Table - Glucophage release forms
| Title | Appointment | Basic rules for admission |
|---|---|---|
| Glucophage 1000 | - It is used for severe forms of diabetes | - Up to 3 tablets per day |
| Glucophage 850 | - May be an initial or maintenance dose (based on glucose test results) | - Take up to 3 times a day |
| Glucophage 500 | - Standard starting dose for metformin therapy; - suitable for dose adjustment according to sugar indicators | - Up to 6 tablets per day; - as agreed with the endocrinologist |
| Glucophage Long 750 | - It differs from the usual form by the method of administration - 1 time per day | - Maximum dose - 3 tablets per day once |
| Glucophage Long 500 | - It is taken once a day; - initial dose of a prolonged form | - The maximum can be taken up to 4 tablets per day once |
More about schemes
In order to reduce weight, a regimen is acceptable with a minimum dose of the drug and the simplest mode of its use. This is Glucofage 500, taken on a tablet, three times a day. An increased dosage of Glucofage can only be prescribed by a doctor for direct indications, and also taking into account the reaction of the body in the form of changes in sugar titers, measured on an empty stomach and after eating.
If the triple regimen of the patient is not satisfied, you can purchase a prolonged form of the drug. A significant difference in the action of the prolonged and the usual forms is based on the time to reach the maximum concentration of metformin in blood plasma. An ordinary drug reaches it two and a half hours after administration, is excreted faster, and prolonged - it concentrates after four hours, is excreted throughout the day.
Consider the possibility of taking a prolonged form if necessary, increase the dose. The use of Glucofage Long 750 is allowed in an amount of up to three tablets at a time, which will significantly increase the concentration of metformin throughout the day.Losing weight at Glucofage, you should adhere to the following recommendations:
- take the drug at one time;
- combine reception with a meal;
- drink a tablet with half a glass of water;
- eat low-carb foods;
- provide a normal drinking regime;
- physical activity to limit exercise.
The usual "Glucophage" is taken two or three times a day. Prolonged - once, preferably at night. This will ensure a decrease in appetite for the next day.
Special instructions for losing weight. Harm and Benefit
When using Glucophage for weight loss, even with its normal tolerance, one should not forget that this is a medicine that has contraindications, features of use and a number of side effects. A pharmacological substance is capable of unexpected interactions, which is also worth considering when preparing to lose weight with its help.
About side effects
Glucophage and its analogs in composition (Siofor) are considered the safest means for the treatment of type 2 diabetes mellitus, since they do not affect the production of insulin and therefore do not carry the risk of developing hypoglycemic coma. When examining the drug, its safety for the liver was noted. Among the frequently encountered side effects, the manufacturer mentions dyspeptic disorders, they are manifested:
- nausea
- vomiting
- loss of appetite;
- stool disorders;
- flatulence.
Such actions accompany a violation of the recommendations regarding the dose and regimen of the drug. Often they arise at the beginning of treatment and disappear on their own in a few days. For the prevention of disorders, doctors recommend combining the drug with food, increase the dose gradually, divide it into two or three doses per day.
About contraindications
If there is only one indication for the use of the drug, then there are much more contraindications. Among them:
- individual sensitivity reactions;
- acute diabetic conditions (coma);
- renal failure;
- peripheral tissue hypoxia (heart failure);
- alcoholism;
- liver damage;
- during pregnancy;
- lactation.
Why you can not assign "to yourself"
Reviews from the Glucofage diet pills contain information on the positive effect of the drug on glucose tolerance, the dynamics of treatment for PCOS, weight loss during therapy, which led to a long-awaited pregnancy. However, this information is purely introductory in nature, and any actions for polycystosis should be coordinated with the doctor. The drug is not recommended for healthy women during menopause, since against the background of hormonal changes, the development of resistance of cells to their own insulin is possible.
In some cases, successful weight loss depends on a visit to a nutritionist and a professional selection of measures to lose kilograms. According to slimming reviews, the negative consequences of taking Glucofage are rare, because most people stop drinking pills at the stage of dyspeptic disorders at the beginning of treatment. "Glucophage" for weight loss can only be recommended by an endocrinologist. Otherwise, the responsibility for the consequences rests on the shoulders of the losing weight.
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