"Indomethacin": what kind of pain the medicine will help get rid of

Indomethacin ointment is used for various diseases, inflammatory processes and has a good therapeutic effect - from back pain to acne treatment. Indomitacin suppositories and injections are also often used, like tablets. If you want to find out on the Internet what else this drug treats, whether it is suitable specifically for your case - enter the name in the search line correctly - indomitacin, indomethocin, indomecin is the wrong name variant.

The main complaint for any gynecological pathology is pain in the lower abdomen. These unpleasant symptoms interfere with normal life, especially during critical days. There is a large list of pain medications, but Indomethacin has clear advantages in some areas.

Composition and principle of action

The drug "Indomethacin" contains the active substance of the same composition. The medicine belongs to non-steroidal anti-inflammatory drugs (NSAIDs). "Indomethacin" inhibits inflammation enzymes (COX-1 and COX-2), which play a decisive role in the formation of tissue edema and pain. Also, "Indomethacin" has an antipyretic effect. The drug reduces platelet aggregation (gluing), improving blood properties, which is especially important for inflammation.
Thus, the range of indications for the appointment of "Indomethacin" is as follows:

• pain syndrome of any nature - inflammatory and non-inflammatory origin (for example, articular), acute and chronic in nature;
• decreased activity of inflammation - reduces pain, tissue swelling, improves local blood circulation, has an antipyretic effect.

"Indomethacin" when applied orally and rectally metabolized in the liver. It is excreted mainly with the kidneys, actively penetrates into breast milk during lactation.

When used

Most often, "Indomethacin" is used to relieve pain associated with inflammation of the elements of the musculoskeletal system. Namely:

• osteochondrosis;
• rheumatoid arthritis;
• psoriatic joint damage;
• gout;
• rheumatism;
• ankylosing spondylitis and arthrosis of the joints.

In gynecology

It is also prescribed for toothache, headache, with ENT diseases. Indications for the use of "Indomethacin" in gynecology are situations associated with the occurrence of pain in the following diseases:

• algomenorrhea - to relieve pain on any day of bleeding during menstruation;
• endometriosis - pathology is accompanied by "shooting" or aching pains in the sacrum, lower abdomen, rectal region;
• ovarian cysts - in the complex anti-inflammatory treatment;
• uterine fibroids - in case of malnutrition of myomatous nodes with signs of inflammation;
• ovulatory syndrome - with arising pains in the lower abdomen in the middle of the cycle;
• adnexitis - the drug is part of a comprehensive treatment for inflammation in the area of ​​the appendages.

Also, "Indomethacin" can be prescribed for relief of pain during exacerbation of hemorrhoids or anal fissure, with acute cystitis.

During gestation

The drug can be used during gestation to relieve pain associated with inflammation, diseases of the musculoskeletal system. Treatment with "Indomethacin" is also carried out in case of threatened abortion:

• with uterine tone;
• with cramping pains.

This use is due to the fact that prostaglandins play an important role in the process of contracting myometrium and opening the cervix. By blocking these enzymes, you can stop the "trouble".

The most effective use of "Indomethacin" with an immature cervix. In this case, Indomethacin therapy is based on the following postulates:

• conducted by a course lasting five to ten days;
• maximum course dose - 1000 mg;
• optimal use of the method from 16-18 to 32-34 weeks of gestation;
• the effect develops after two to three hours from the start of treatment;
• it is advisable to supplement with magnesium preparations, for example, electrophoresis with magnesia.

A prerequisite is compliance with the course dose. Exceeding it or using the drug after 34 weeks can lead to premature closure of the arterial (botall) duct in the fetus, which is necessary during fetal life to "bypass" the lungs that do not function during this period. Normally, closure occurs at birth or during the first three days.

Features of the drug with uterine tone are described in the table.

Table - How to properly remove the tone of the uterus and the threat of premature birth with the help of "Indomethacin"

Instructions for use "Indomethacin"

For treatment, tablets, rectal suppositories, and injections may be used. Ampoules with indomethacin are available in 1 ml each with an active ingredient content of 0.03 g. They are used in practice much less frequently than tablets and suppositories. Separately, eye drops with indomethacin are released.

Pills

The dosage of Indomethacin tablets may be 25 mg and 75 mg. The application scheme is as follows:

• standard dose - 25 mg two to three times a day;
• if necessary - can be increased to 50 mg three times a day;
• maximum dose - with a short regimen is 200 mg / day, with prolonged use - 75 mg / day.

Candles

The use of suppositories "Indomethacin" in gynecology and general therapeutic practice is limited to the following schemes:

• 50 mg candles - one one to three times a day;
• 100 mg candles - one at night;
• maximum dose - 200 mg during bouts of pain.

Ointment

Apply the ointment to the skin over the painful area. The rubbing area is approximately 4-5 cm, it is acceptable to use every four to six hours. The maximum permissible dose per day is 15 cm of ointment squeezed from the tube.
Reviews about the ointment "Indomethacin" indicate its effectiveness in the treatment of varicose veins with inflammation, with pain in the lower back, in the joints, with bruises and sprains.

Contraindications

The COX-1 and COX-2 enzymes are distributed throughout the body. Therefore, the effect of the use of "Indomethacin" is reflected in all systems and organs. The following conditions are a contraindication to use:

• ulcers of the stomach and duodenum;
• active bleeding in any part of the body;
• congenital heart defects;
• bronchial asthma;
• cirrhosis of the liver;
• renal failure;
• blood clotting disorder;
• epilepsy and mental illness.

Possible consequences of taking

The most dangerous side effect of taking “Indomethacin” is ulceration of the gastrointestinal mucosa, but it is observed only with prolonged use of the drug in high doses in individuals predisposed to such complications. For example, if a history of gastrointestinal ulcers (GIT), with exhaustion. The following side effects of the drug are also possible:

• from the gastrointestinal tract - nausea, vomiting, discomfort in the abdomen, loose stools, impaired liver function;
• from the nervous system - headache, dizziness, irritability, drowsiness, fatigue, impaired sensitivity;
• on the part of hearing and sight - double vision, conjunctivitis, tinnitus;
• from the heart and blood vessels - increased pressure, worsening heart failure, if any;
• from the kidneys - the appearance of protein, red blood cells, cylinders in the urine;
• blood side - a decrease in coagulability and a tendency to bleeding;
• allergy - urticaria, Quincke's edema, anaphylactic shock;
• local reactions - itching, burning, redness at the site of application of the ointment.

An overdose with rectal use or a drug in the form of an ointment does not occur. In case of excess doses when taken orally or injected, the possible consequences of admission from all systems and organs are exacerbated. In this case, you should immediately consult a doctor, the treatment is symptomatic.

special instructions

To prevent the development of side effects from drugs, the following possible interactions should be considered:

• enhances the effect of other NSAIDs - aspirin, "Ibuprofen";
• reduces the effect of diuretics - "Spironolactone";
• reduces the effect of thrombolytics - “Alteplases”, “Streptokinases”, “Urokinases”;
• cannot be combined with alcohol - this increases the likelihood of bleeding from the digestive tract;
• lowers blood sugar - while taking insulin preparations or other hypoglycemic agents, it can provoke a sharp drop in glucose levels.

Analogs

Among the complete analogues of the active substance, the following groups of drugs can be distinguished:

• "Metindol";
• "Indomethacin-Acra";
• "Indocide";
• "Indotard."

If necessary, you can choose another drug that helps like "Indomethacin" and also belongs to the group of non-steroidal anti-inflammatory drugs. The popular list is as follows:

• Ibuprofen
• "Nimesil";
• Ketanov.

Reviews of doctors indicate that often you have to choose the most suitable NSAIDs by trial and error for a particular patient.

The widespread use of candles "Indomethacin" in gynecology due to their effectiveness, simplicity and ease of use. But you should take the medicine only on the recommendation of a doctor, since only a specialist can choose a scheme, make sure the medicine is safe and necessary. Self-administration can blur the clinical picture of the disease and increase the likelihood of complications.

Reviews

I was prescribed with the threat of premature birth. I did it for three days, and then it became very bad - dizziness, nausea, pressure jumped. A nurse in the department said that many pregnant women did not tolerate indomethacin well, after which the drug was canceled.

Sasha, https://www.baby.ru/u/izumina/

I was also prescribed this drug because of uterine hypertonicity, I put candles for 3 days. (helped) The only restriction is that it can be put no more than 1000 mg for the entire pregnancy. therefore, we must consider that we would not go beyond the scope, but the doctor should have warned you about this. And my advice to you is not to read any information on the Internet, and your doctor knows what and when to prescribe. Better ask all the questions and don’t worry)

Mary D, http://38mama.ru/forum/index.php?forumsess=khv7rprpjki3r2rg9ijt5o8cd0&action=profile;u=19727

When I went to the gynecologist, I was found to have inflammation, and more specifically the excess of leukocytes.After which I was prescribed these drugs: vaginal tablets, rectal suppositories indomethacin, tablets Trichopolum and to consolidate treatment, in cases of prevention dysbiosisvaginal suppositories acylactprobiotics linex. This drug in combination with other means, undoubtedly helped me in the treatment!

Kseniyavysockaya, http://irecommend.ru/users/kseniyavysockaya

There are no chronic diseases, I acquired candles as prescribed by a gynecologist. On the first day after entering 100mg, side effects began, the head ached immediately, an hour later a terrible heartburn, nausea, vomiting began ...

Julia Goman,http://www.happy-giraffe.ru/community/33/forum/post/26889/

I am not allergic, at least I have never had any contraindications to any drugs. "Indomethacin" was prescribed as a painkiller for a functional ovarian cyst in the form of rectal suppositories at night. At the first application, after 5 minutes, a strong heartbeat began, some tremors, dizziness and breathing problems. I was very scared, took this candle out of myself, washed it and drank a large amount of water. I did not stop there, I tried the experience the next evening. She lasted 10 minutes by force of will, but then the same thing began. I won’t experiment anymore. This is a dangerous drug, it seems.

+ 7-916- 31XXXXX, https://protabletky.ru/indometacin/#otzivi

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