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The spectrum of antifungal drugs is large. But many of the microorganisms are able to acquire resistance to the action of drugs. Especially with regular use. The described drug is highly effective in the treatment of not only candidiasis, but also other fungal diseases. And reviews of Irunin confirm this.
Composition and effect of the drug
Irunin is produced in capsules and vaginal tablets (not in suppositories). The main active ingredient is itraconazole, the content of which in the capsule form is 100 mg and 200 mg in tablets. The characteristics of the forms are as follows.
- Hard capsules. Made of gelatin, their color is yellow, inside contain sphere-like white pellets. Available in packs of ten. Auxiliary components of this form of release are eudragit, nipazole, sucrose, titanium dioxide, nipagin, dyes, starch syrup.
- Vaginal tablets. Ring-shaped, white, ten pieces per pack. Their additional components are: milk sugar, talc, starch, magnesium stearate, povidone, sodium lauryl sulfate.
Itraconazole has a detrimental effect on fungal cells. Penetrating into the pathogen, it slows down the production of ergosterol, a specific enzyme by its membrane. This contributes to the destruction of pathogenic fungi, and they do not spread throughout the body.
The features of the drug include the following:
- necessary concentrations - are achieved only with prolonged use;
- accumulation occurs - mainly in tissues with keratin, for example, in the skin;
- metabolized - in the liver;
- completely displayed - with feces and urine, only a week after the end of the course of therapy;
- with vaginal use - practically not absorbed into the blood, but acts locally.
The following types of fungal microorganisms are most sensitive to the drug component:
- mold and yeast - candida, aspergillus, blastomycetes;
- dermatomycetes - trichophyton, microsporia.
Indications
The capsule form of the drug is widely prescribed for systemic diseases. Indications for the use of Irunin are the following situations:
- complex therapy - infections of a fungal nature;
- prevention of dysbiosis - against the background of taking medication;
- mycoses - skin of the body and head (scalp), with seborrhea and eczema, as well as cryptococcosis;
- deprive - It is prescribed for shingles, multi-colored (pityriasis), ringworm;
- candidiasis - in which mucous membranes are affected, as well as deep visceral candidiasis with damage to internal organs, systemic aspergillosis and candidiasis;
- onychomycosis - nail fungus;
- prostatitis - fungal nature.
Irunin in the form of vaginal tablets is used for vulvovaginal candidiasis. Moreover, not only for the treatment of the acute form of the disease, but also with recurrent thrush.
When the product cannot be used
Not everyone can take the medicine. The table shows the relative and absolute contraindications for admission.
Table - Conditions in which treatment with Irunin is undesirable or prohibited
| Strongly should not be taken | Take with caution |
|---|---|
| - Hypersensitivity to any of the components of the drug; - first trimester of pregnancy; - lactation | - Pathology of the liver; - heart failure; - age up to 18 years |
It is necessary to inform the doctor about the use of any other medicines, since Irunin may not be combined with some of them.
Instructions for use "Irunina"
For maximum effect, the capsule form should be taken with food or immediately after, swallowed whole. The duration of treatment and the frequency of administration depend on the particular disease and in each case are determined individually. The main treatment regimens are presented in the table.
Table - Features of the “Irunin” treatment course for various diseases
| Pathology | Dosage "Irunina" and features of its reception |
|---|---|
| Lichen | 2 capsules in 1 dose per day for 7 days |
| Mycosis of smooth skin | - 2 capsules in 1 dose per day for 7 days; - with damage to the feet and hands 100 mg for 15 days |
| Oral candidiasis and intestinal fungus | 1 capsule per day for 14 days |
| Keratitis of fungal etiology | 2 capsules in 1 dose per day for 21 days |
| Aspergillosis | - 2 capsules 1-2 times a day (depending on the form of the disease); - treatment lasts from 1 to 5 months |
| Onychomycosis | Option No. 1 (pulse therapy): - 2 capsules 2 times a day for 1 week, followed by a break of 3 weeks; - with lesions of the feet, 3 such courses are carried out, 2 hands; |
| Option number 2 - continuous medication 2 capsules 1 time per day for 3 months |
The optimal effect of treatment can be observed after 6 months with nail damage and two to four weeks with skin mycoses.
Side effects
When using Irunin capsules, patients may experience side effects of the drug. The main ones are indicated in the table.
Table - Complications of the internal reception of “Irunina”
| Body system | Complications |
|---|---|
| Nervous system | - Dizziness; - severe fatigue; - cephalgia; - sometimes peripheral neuropathy |
| Digestive organs | - Nausea; - discomfort in the abdomen; Vomiting - cholestatic jaundice; - dyspepsia; Constipation - cases of toxic hepatitis with the development of liver failure are described |
| Reproductive system | Dysmenorrhea |
| The cardiovascular system | - Heart failure; - pulmonary edema |
| Skin side | - Rash; - hair loss; - itching; - urticaria; - angioedema |
| Exchange disorders | - Hypokalemia; - swelling |
| urinary system | - Creatinine rises, while urine becomes dark |
As a result of the use of vaginal tablets, local reactions are sometimes observed in the form of mild itching and burning in the vagina, rashes on the genitals. In this case, do not interrupt treatment with the drug if the signs do not progress, but pass.
Analogs
There are many analogues of the drug. Some of them:
- Mikomax - antifungal drug in capsules, the active substance is fluconazole;
- Mikoflukan - a systemic antimycotic agent, in which there is fluconazole;
- «Rumycosis» - a budget analogue of "Irunin", available in capsules, the active substance itraconazole 100 mg each;
- Itrazol - capsules based on 100 mg of itraconazole.
special instructions
Sometimes it is necessary to increase the dose to patients in whom the immune system is provoked. For example, there is neutropenia, HIV infection, a condition after an organ transplant.
It is undesirable to take the remedy for patients with diseases of the kidneys, liver, and heart failure. Exceptions are cases where the expected effect is higher than the probability of possible complications.
Monitoring the liver when taking the medicine should be once a month.
When using the vaginal form of the drug, you need to refrain from sexual intercourse and simultaneously treat two partners.
The features of interaction with other drugs are as follows:
- reduce effect - “Rifampicin”, “Difenin”, “Carbamazepine”, “Phenobarbetal”;
- enhance the effect - "Erythromycin", "Ritonavir."
The widespread use of Irunin in dermatological and gynecological practice has proven its effectiveness and good tolerance. The official instructions do not contain data on a possible overdose of the medication; the doctors' reviews also do not contain such information. If, nevertheless, a large dose of the drug was taken, for an hour you need to rinse your stomach and take Activated carbon. Symptomatic treatment is carried out. There are no specific antidotes.
Reviews: “On the third day, spots on the skin almost disappeared”
I, too, was treated with irunin according to the pulse therapy scheme (there is one in the instructions), I dripped exoderil onto a cleaned nail and some kind of antifungal ointment ... My nail slowly grew healthy, and it was such a deep fungus that even the sensitivity on the thumb was gone ...
a guest, http://www.woman.ru/health/medley7/thread/3943641/2/
2 years with periodic success struggled with multi-colored lichen. The talkers only helped for a while. On this basis, survived to neurosis. The last conclusion of the dermatologist is seborrheic dermatitis, weeping. She began taking Irunin in combination with vitamins, sedatives and linden tea. On the third day, almost all spots on the skin disappeared (even skin tightness disappeared), itching and dandruff still remained, but hope for healing appeared .. I hope for positive results, but for now I continue treatment ...
Olga, http://www.tiensmed.ru/news/irunin-a2h.html
He treated the fingernails affected by the fungus in different ways for about 5 years. On the recommendation of a doctor, I tried irunin. After 2 courses (14 tablets), the nails were completely cleaned. New branches and no problems for 5 years. I read about the side effects in the instructions, but nothing happened.
Yuri, http://www.tiensmed.ru/news/irunin-a2h.html
When I was examined by a gynecologist, she prescribed Irunin for candidiasis. Irunin took two capsules 2 times a day after breakfast and dinner. A total of 3 days was treated. During the course, the symptoms almost disappeared. But literally three days after the end of treatment, they began to resume. I didn’t have a sexual partner then, so the infection option disappears. It turns out, I just threw the money away. Later I read that he still has a long list of side effects, but I, fortunately, did not show them. I will not argue that the drug is completely useless, but for me personally it turned out to be just that.
Lora, http://doctorsforum.ru/viewtopic.php?f=32&t=427
Three years ago, the eldest son discovered spots of multi-colored lichen. For a month they tried to cure him with various gels and ointments. In the end, they were examined by a dermatologist, and he advised antifungal pills to choose from. I decided to buy Irunin, because it was the most inexpensive (only 300 rubles - packaging). Compared to Orungal, which costs 2,000 rubles, this is a penny. I gave my son two capsules after breakfast for three days, as recommended in the instructions.My son transferred the drug normally, there were no side effects, at least visible. On the third day, lichen began to go away, and after 10 days only a trace remained.
Spring, http://doctorsforum.ru/viewtopic.php?f=32&t=427
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