The content of the article
Adhesions are cell growths. Often they are compared with threads, since they connect organs and tissues to each other, for example, the intestine, uterus and the surface of the peritoneum, the rectum and the cervix. In these "threads" pass vessels, nerves. Even the physiological movement of organs causes tension of adhesions and pain. In addition, the adhesion process can "close" the lumen of the fallopian tubes and cause infertility. Such filaments can form in any part of the genitals - the uterine cavity, cervical canal, and vagina.
Composition and principle of action
“Longidase” refers to enzyme preparations and contains bovgyaluronidase, an “improved” version of the natural human enzyme. Candles for rectal and vaginal use are most popular, but the drug is also available in ampoules for intramuscular and subcutaneous administration. The main properties of the drug are as follows:
- anti-inflammatory;
- antioxidant;
- immunomodulatory;
- enzymatic.
Best of all, Longidaza acts as a prevention of adhesions. In this case, its antifibrotic properties are due to the following:
- reduces the number of inflammatory mediators in the focus - they damage tissues and contribute to the further formation of adhesions in them;
- resistant to high temperatures - the usual enzyme hyaluronidase at 37 ° C ceases to work, which is why most often adhesions are the consequences of complicated healing, with temperature and suppuration;
- inactivates collagen stimulants - it is from it that the commissures “build”;
- acts on glycosaminoglycans - this is a component of already formed “threads”, destroying the bonds between glycosaminoglycans, hyaluronidase reduces the tension of adhesions, relieves swelling, increases the mobility of previously fixed parts of organs.
Benefits
Longidase is a safe medicine. According to the instructions, the drug has the following advantages:
- does not increase the risk of cancer;
- does not suppress actively dividing cells;
- does not affect the eggs and sperm;
- does not cause allergic reactions;
- does not impair tissue healing;
- does not provoke the development of inflammation;
- does not slow down bone recovery after surgery;
- does not accumulate in tissues;
- distributed evenly throughout the body;
- the bioavailability of the drug in suppositories is about 90%;
- maximum concentrations in the blood are reached after an hour;
- enhances the effect of painkillers and antibiotics.
When used
Suppositories "Longidaza" are prescribed for all diseases where there is hyperplasia (pathological proliferation) of connective tissue. The range of applications covers a list of ailments.
- Urology. With narrowing of the ureter and urethra, with acute and chronic cystitis, with prostatic hyperplasia, for the prevention of scar formation after performing surgical operations on the organs of the urinary system.
- Dermatovenerology. In diseases of the connective tissue (for example, scleroderma), for the prevention of scarring and narrowing during active inflammation.
- Surgery. In order to prevent an active adhesive process on the abdominal organs after operations, as well as to improve the healing of complex wounds.
- Pulmonology. It is used for tuberculosis, pneumosclerosis and other processes in which the lung tissue is replaced by connective tissue.
- Orthopedics. During the treatment of joint contracture, spondylarthrosis.
The use of Longidaza suppositories in gynecology also has a wide range of diseases. The drug is used:
- in complex treatment of follicular ovarian cyst;
- with infertility of the tube factor;
- with adhesions inside the uterine cavity;
- with chronic and acute adnexitis;
- in any form endometritis, cervicitis;
- after operations and laparoscopy;
- after minor manipulations (curettage, abortion);
- at endometriosis.
Candles "Longidaza" with endometriosis, adhesive disease, with ovarian cyst and infertility, as well as for the prevention of other complications due to hyperplasia of the connective tissue is the means of choice.
Instructions for use "Longidazy"
Indications for use, as well as the form of the drug (injection or suppository) can only be determined by a doctor. The duration of therapy may vary, as well as treatment regimens in specific situations.
Candles
The standard treatment regimen “Longidaza” includes laying candles in the rectum or vagina every day or every two to three days. The total duration of treatment is usually from 10 to 20 suppositories administered, which is about two months.
If necessary, the course of treatment can be repeated every three months. If "Longidaza" is used for maintenance therapy, candles should be placed every five to seven days for three to four months. You can lay suppositories as follows.
- Vaginally. It is convenient to lay at night in a supine position, it is also possible to introduce candles in a half-sitting position. During menstruation, you must either cancel the use of suppositories, or use "Longidaza" in the rectum.
- Rectally. Before the introduction of the suppository, it is necessary to empty the rectum, conduct basic hygiene procedures. To lay also in a prone position or half-sitting. You should not use this route of administration for exacerbation of hemorrhoids or proctitis.
Injections
"Longidase" is administered only intramuscularly or subcutaneously, intravenous injection cannot be performed. The basic principles of drug therapy are as follows.
- One ampoule is introduced. It contains 3000 IU of the active substance. Before administration, the lyophilisate (contents of the ampoule) must be diluted in 1-2 ml of 0.25% or 0.5% Procaine or in 0.9% sodium chloride solution (physiological solution).
- Used scheme for introductions. Most often, injections are prescribed with a frequency of once every three to five days. The duration of treatment is determined by the doctor, on average, the course is from five to twenty injections.
Who is not allowed
Despite the relative safety of "Longidaza" and good tolerance, there are contraindications to the drug. They include the following:
- hypersensitivity to the components of the drug;
- bleeding from the lungs;
- vitreous hemorrhage;
- detected oncological diseases;
- renal failure;
- not recommended during pregnancy and lactation.
Complications of Reception
Reviews of doctors and women who used the drug indicate the following possible side effects:
- soreness - at the injection site when using injections;
- itching, redness, slight swelling - at the injection site or in the vulva and vagina.
special instructions
Often, suppositories or injections of "Longidase" are prescribed in a complex anti-inflammatory treatment. In such situations, it is necessary to take into account the possible interaction of the drugs and the strengthening of the expected therapeutic effect of the drugs. This effect is especially observed when “Longidases” are combined with antibiotics, diuretics, and painkillers due to an increase in their bioavailability for the body.
Salicylates, drugs based on estrogen and glucocorticosteroids can reduce the effectiveness of Longidase.
Taking the drug is not advisable to combine with the use of alcohol. "Longidaza" does not affect the speed of the mental reaction, therefore, during treatment, you can lead a normal lifestyle and do all the work.
Analogs
Full analogues of the drug do not exist. Among drugs with a similar effect, the following can be distinguished:
- Wobenzym - contains a complex of plant enzymes and obtained from animals;
- Lidaza - contains hyaluronidase as an active component;
- Phloenzyme - a complex of three enzymes.
The effectiveness of "Longidaza" depends not only on the timeliness of the appointment, but also on the characteristics of the woman's body. They can use both injections and suppositories. Reviews about the candles "Longidaza" indicate simplicity, ease of use and almost no side effects.
Reviews: “Put 10 injections. Since 2007, spikes have not bothered ”
Hello! I am new to the site. My gynecologist prescribed 10 injections of longidase plus candles with polyoxidonium due to the fact that a small polyp (endometrium, 3 mm) was found on my ultrasound. I did some injections, a little painful. The next cycle came - no one polyp and no suspicion was found. Longidaza also prevents tissues from growing and soothes inflammation very well, but I think it’s unlikely to “cure” adhesions, it is more likely to be an adjuvant or since adhesions tend to grow and come back — longidaza prevents this. Although now (already a year has passed after that) I again have a suspicion of a polyp, though it is already larger. Probably again they will propose to pierce the longidase ....
Pisolkin, http://www.babyplan.ru/user/12591-pisolkin/
I am already completing a course of 10 injections, given 1 injection every 5 days, against the background of injections, G. took another Wobenzym + physiotherapy as indicated by the injections, the result is now visible, rather noticeable, the tension on examination of G. disappeared, it smears less after M. Diagnosis of endometriosis. As for the fact that these injections are more painful, this garbage, girls, sulphurous magnesia are many times “more pleasant”. From the unpleasant sensations there was a slight redness of the buttocks and itching. And it is better to buy injections in packages of 5 pcs., So that later on the body perceives the drug.
Lizzie, http://www.babyplan.ru/user/12103-lizzi/
It was a long time ago - 7 years ago.A good gynecologist advised me, oooooooooo - I could not get pregnant for several months, I decided not to delay - when we have not been able to for a year))))) she found an inflammatory process in me. I did injections of Longidaz. 5 items. Once every 5 days. - keep them in the refrigerator. Sick they are - these injections)))) after 5 months - became pregnant and gave birth.
Katyusha https://deti.mail.ru/id1013864976/
I have had postoperative adhesions in the pelvis since 2002. About once every half a year, exacerbation occurred, the pains were such that you can not describe! Sometimes they even called an ambulance because I could not get out of bed. And so it happened for several years. After another hospitalization, my gynecologist prescribed Longidaz to me. Put 10 injections. Since 2007, spikes have not bothered. This is a miracle drug !!!! Recomend for everybody!
Galina, http://www.woman.ru/health/medley7/article/45866/
Hi. I had a course of Longidaza in the spring 10 times every 5 days. Assigned to treat hr. endometritis. Well, in general, I did not have a pronounced inflammation. Just M were very painful and very plentiful. Therefore, the treatment was without antibiotics. Among other things, I was prescribed physiotherapy (first a magnetic laser, then an ultrasound), immunomodulating candles and homeopathic injections for building up the endometrium. About Longidaza read only the good. Well, if in fact. I can’t say that I see a specific result. M remained as plentiful, after them it still smears for a long time. BT in the first phase is a bit high. Before treatment, she was even better. Therefore…..
denken http://forum.forumok.ru/lofiversion/index.php?t43263.html
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