The content of the article
"Nystatin" refers to polyene antibiotics with antifungal activity. It is available in the form of ointments, vaginal and rectal suppositories, lozenges, there are still drops, that is, the form "for all occasions." The properties of the drug allow it to be used during pregnancy and gestation without fear for the health of the unborn baby.
How does nystatin work and how
The composition of the drug includes the same active substance - nystatin. It belongs to natural antibiotics and is naturally synthesized by actinomycetes.
"Nystatin" is effective only against fungi of the genus Candida. It interacts with the elements of the cell wall of microorganisms, forming "gaps". This leads to an imbalance between the flow of nutrients and water into the cell and the release of metabolic products. As a result, candida nutrition is disrupted and their reproduction is inhibited. Thus, "Nystatin" has a fungistatic effect - inhibits further division of fungi, but does not cause their death. After a short life cycle, candida die. Therefore, during treatment it is important to comply with the prescribed scheme so as not to provoke a relapse of the disease by activating forms that have not yet died.
The main advantages of the drug are as follows:
- sustainability is slowly developing - the drug in the field of application (for example, in the vagina when using suppositories) creates high concentrations of the active substance;
- well tolerated - "Nystatin" is insoluble in water, so it is quite difficult to penetrate into the systemic circulation when ingested, and even more so when used locally;
- can be applied to all groups of individuals - given the minimal side effects, the drug is recommended for the treatment of even the elderly, pregnant women and children.
When to use
The only indication for the use of Nystatin is a fungal infection of the skin and mucous membranes. A complete list of pathologies is presented in the table.
Table - When Nystatin is prescribed
| Sanitation of the vagina and external genital organs | Remediation of the gastrointestinal tract | Skin diseases |
|---|---|---|
| - Acute candidiasis; - prevention of exacerbations in chronic form; - prevention of thrush while taking medication; - genital candidiasis in men | - Oral candidiasis, for example, stomatitis, gingivitis, glossitis, fungal tonsillitis; - prevention of dysbiosis against the background of taking antibiotics, cytostatics, hormonal drugs; - prevention of flora disorders in the pre- and postoperative period | Primary and secondary skin candidiasis |
Perhaps the appointment of "Nystatin" with pink lichen, psoriasisdandruff. However, alternative treatment is best done with a specialist. Depending on the disease, a specific dosage form or even a combination of several is used for greater effectiveness.For example, with genital candidiasis, it is recommended to combine treatment with nystatin ointment and suppositories at the same time.
Instructions for use "Nystatin"
The dosage of "Nystatin" during treatment should be established by the attending physician. Standard schemes are presented in the table.
Table - Nystatin treatment regimens depending on the form of the drug
| Form of medicine | Dosage | Application features |
|---|---|---|
| Ointment | - In one tube of 15 or 25 g of ointment; - in 1 g - 100 000 IU of active substance | - Apply a thin layer twice a day for 1-2 weeks; - use as a dressing, change daily, the same course of treatment |
| Vaginal suppositories | - 250,000 units in one suppository; - 500,000 units in one suppository | - Lay in the morning and evening one candle after washing; - continue treatment for 10-14 days |
| Rectal suppositories | - 250,000 units in one suppository; - 500,000 units in one suppository | - Lay twice a day in the rectum after bowel movements and hygiene; - do not use with exacerbation of hemorrhoids |
| Pills "Nystatin" | - 250,000 units in one tablet; - 500,000 units per tablet | - In case of candidiasis of the oral cavity, it is necessary to dissolve one tablet 2-8 times a day for a week; - with candidiasis of the intestines, take inside, without chewing, from 4 to 8 times a day, depending on the form of the disease |
To whom the drug is contraindicated
Reviews on "Nystatin" indicate good tolerance to the drug. Due to the small systemic effect, it can be used even during pregnancy, lactation, in persons with minor impairment of liver and kidney function. The following conditions are contraindications for prescribing a medicine:
- allergic reactions to the drug;
- liver failure;
- peptic ulcer of the stomach and duodenum;
- renal failure;
- leukopenia (decrease in white blood cells).
Complications of Reception
Pills, ointment and suppositories "Nystatin", according to reviews of doctors and patients, most often do not give pronounced side effects. But the following possible reactions to taking the drug are noted in the instructions:
- feeling of nausea and even vomiting;
- relaxation of the stool;
- dizziness;
- chilliness.
Analogs
There are no complete analogues to the drug. Natamycin-based medicines (for example, “Pimafucin") Belong to the same group and have similar properties. In gynecology and obstetrics, combined candles are used, which include nystatin. For example, "Terzhinan», «Polygynax". They have established themselves as effective and safe suppositories even during gestation.
special instructions
When taking Nystatin, possible drug interactions should be considered. The main warnings are as follows:
- «Clotrimazole - activity of "Clotrimazole" decreases;
- Polymyxin, Nifurotel - increase the effectiveness of "Nystatin";
- antacid drugs - reduce the effect of "Nystatin";
- penicillins, cephalosporins - reduce their bactericidal effect when combined with "Nystatin";
- oral contraceptives - breakthrough bleeding and daubing are possible with the combination of Nystatin with them.
The use of "Nystatin" with thrush It is well founded and is an effective treatment.But the drug should be prescribed only by a doctor, preferably taking into account bacteriological culture (vagina, intestines) for sensitivity. The medicine, even after the first application, helps get rid of itching, burning, and reduces discharge.
Reviews: “Divorced from thrush for 7 years”
Low price, affordable and effective drug that really helped. I have been using it for 2 years, after expensive drugs that did not help at all, this is the only means that have paid off. Used according to the instructions, no more than 7-10 days, as well as for prevention from thrush. After several applications, I forgot what thrush is, I immediately felt comfort and unpleasant sensations took off like a hand.
Julia K., https://protabletky.ru/nystatin/#otzivi
Nystatin ointment is almost always in my medicine cabinet. It is known that nystatin tablets can be bought only by prescription, and ointment - without problems. I usually use it with thrush, outside. Women know that when immunity is weakened, thrush often manifests itself - after all, fungi are always in the body in a small amount, and when immunity is weakened, they can aggressively multiply. The texture of the nystatin ointment is slightly oily, it is better to use a pad, but the ointment instantly calms and softens the mucous membranes.
No name, https://www.piluli.ru/product/Nistatin/review
Sick a month with severe flu and as soon as I got out, the drug thrush started after antibiotics. I bought Nystatin in candles, it really helps quickly, after the first candle I felt relief, but the candles were very unpleasantly greasy, put a gasket overnight so that the laundry would not get dirty.
Alyona, https://www.piluli.ru/product/Nistatin/review
For a long time I suffered from chronic thrush. Expensive drugs gave a short-term result. So far, the doctor has not suggested how to apply nystatin topically. After douching with soda, rinse off the nystatin tablets and lay them deeper in the vagina at night. And for prevention, tampons moistened with an aqueous solution of propolis help well.
Irina, http://www.tiensmed.ru/news/nistatinnus1.html
Nystatin is currently the best drug. For a long time I was treated for thrush with all modern drugs that were only advertised on TV. I managed a lot of money, but the thrush didn’t pass. I went to the clinic and not simple. I passed the tests and they gave me the decoding of the antibiogram, that is, which drug responds correctly to my candida (thrush) and was very surprised that all the modern drugs listed on the list did not show a positive result. And it turned out one nystatin. so think for yourself that the obsolete drug that was used even during the Second World War was not the best solution to the problem! Yes, it’s inconvenient that you need to drink for ten days, but damn it after all these unpleasant sensations that I experienced during my life with the thrush ... it was worth it and what does the antibiotic cost compared to all the pennies. So do not get fooled by advertising and a quick decision in three days, and by the way, I probably subscribe, divorced from the thrush for 7 years))) be healthy!
Regina, http://www.tiensmed.ru/news/nistatinnus1.html
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