The content of the article
In many countries of the world, the drug is not used, but in the territory of the post-Soviet space it is included in second-line drugs for the treatment of urinary tract infections. Reliable modern clinical trials of its effectiveness have not been performed, so we can say that it is often used in the old manner, focusing on the experience of previous generations.
Features of the drug
Nitroxoline tablets are available in a dosage of 50 mg. Perhaps his popularity he owes a low price - from 80 rubles for 50 tablets. Analogs of “5-NOC” and “Nitroxolin-UBF” cost a little more - about 190 rubles for 50 tablets. (Data for February 2018).
The composition of the drug suggests that it is a synthetic antibiotic with a wide spectrum of action. It is able to inhibit the synthesis of DNA molecules in microbial cells, which leads to a bacteriostatic effect.
Nitroxoline activity is shown against the following pathogens:
- staphylococci;
- streptococci;
- corynebacterium diphtheria;
- Escherichia coli;
- Proteus
- Salmonella
- Shigella
- enterobacter;
- Mycobacterium tuberculosis;
- Trichomonas;
- candida.
Instructions for use "Nitroxoline": effectiveness for thrush, inflammation of the appendages, cystitis
What is the drug taken from and how to drink it? Features of the metabolism of a substance determined the scope of its use. Indications for use of Nitroxoline include diseases caused by sensitive microbes:
- cystitis;
- urethritis;
- epididymitis;
- pyelonephritis;
- infected prostate adenoma;
- prostate carcinoma with infection.
It is also possible to use for prophylaxis during operations and invasive diagnostic tests on the urinary organs. Sometimes it is prescribed in gynecology for catheterization of the bladder before surgery for uterine fibroids. But it is ineffective in inflammation of the appendages.
Who is not recommended
Even if there is inflammation of the kidneys, contraindications for taking the medication include the following conditions:
- individual intolerance;
- cataract;
- neuritis;
- polyneuritis;
- liver failure;
- chronic renal failure;
- glucose-6-phosphate dehydrogenase deficiency.
Taking "Nitroxoline" during pregnancy is not recommended. This is especially true for the first trimester.In the second and third, when the fetus is already formed, treatment with the Nitroxoline drug is allowed, but only if the benefit for the mother covers all the risks for the child. When breastfeeding, it is also not recommended to use it for treatment. In some maternity hospitals, medication is prescribed for possible infectious complications from the bladder or kidneys. Especially with urolithiasis.
How to use
The method of application depends on the age of the patient.
- Adults. For a day, the dosage of Nitroxoline is 600-800 mg, which must be divided into four doses. Drink each dose of the drug after six to eight hours. The course of treatment lasts 10-14 days.
- Children. Dosing is based on body weight. For each kilogram, 10-30 micrograms per day is taken. The required dose is distributed during the day into three to four doses.
The treatment regimen for infections of the urinary tract, in addition to Nitroxoline, includes antispasmodics and diuretics with a weak effect. Feedback from doctors about the use of this approach is positive. Similar reviews about Nitroxolin-UBF tablets, which are a complete analogue.
Unpleasant consequences
Side effects have a different degree of severity. These may be the following manifestations:
- nausea;
- vomiting
- a sharp decrease in appetite;
- skin rash allergy;
- heart palpitations;
- ataxia;
- headache;
- polyneuropathy;
- feeling of "creeping creeps" and other paresthesias;
- impaired liver function.
With a very long application, a single case of optic neuritis was observed. You also need to take into account the compatibility of the drug with other drugs.
Special instructions: therapy and alcohol
Long-term treatment with the drug is not recommended due to the development of unpleasant consequences. There should be no concern staining of urine a yellow-red color, which does not require special treatment and passes on its own.
In severe renal impairment, medication should be discarded. As with renal colic, a violation of the outflow of urine will lead to the accumulation of drugs in the blood and increase unpleasant actions.
Patients with diabetes or impaired glucose tolerance should also be careful. The drug’s shell contains sucrose and glucose, which can lead to sugar in the urine.
An overdose of the drug leads to increased side effects. In such cases, you need to induce vomiting or gastric lavage.
Alcohol with Nitroxoline should not be taken at the same time. Alcohol has a negative effect on nerve tissue. "Nitroxoline" has a similar effect, which is manifested in the possibility of developing polyneuropathy and neuritis. The combination of two drugs will only enhance the unpleasant effects.
The use of Nitroxoline for cystitis should be monitored and recommended by a doctor. For this disease, more effective and less toxic drugs have been identified. But this antibiotic must be left in reserve, and besides, you cannot buy it without a prescription.
Reviews: "There are no reminders of the disease ..."
Nitroxoline is very good at treating cystitis. And if you do not rely on instant miracles, but show perseverance and treat them for no more than two weeks, then the results will be very impressive. I have a feeling that cystitis is gone forever. Let's see how long this effect really lasts.
Lily, https://www.piluli.ru/product/Nitroksolin
Periodically gives a pronounced anti-inflammatory effect. Low efficiency, side effects. The drug is quite toxic. The drug was actively used twenty years ago. Over time, efficiency has decreased.Although in some cases it gives a pronounced effect so far. In a word, it can be used now.
Nedoshkulo K. T., urologist https://protabletky.ru/nitroxoline/
"Nitroxoline" had to be taken after an accidental swim in the hole. I can judge objectively. The pain was very decent. After the first day of taking this medicine, it was much easier. I drank three times a day. He recovered quickly enough. In about ten days. I did not observe any troubles during the reception. Only urine is slightly stained. After a full course of treatment and following all the doctor’s recommendations, the disease did not recur. No reminders left.
Sergey R., https://protabletky.ru/nitroxoline/
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