Norbactin tablets: how to use it in case of genitourinary and intestinal infections

The composition of the drug includes the main active substance norfloxacin. It belongs to the second generation fluoroquinolones. These drugs were obtained by chemical synthesis from nalidixic acid, on the basis of which a number of quinolones were derived. Then fluorine atoms were added to them, which led to an increase in antimicrobial activity.

How does the medicine bactin

The mechanism of action of the drug is based on the suppression of the activity of the cellular enzyme DNA gyrase. This leads to impaired function of the nucleic acid - it does not allow the synthesis of proteins necessary for the life of the microbe, the bacterium dies. Also, the effect is due to the indirect effect on the RNA of the bacterial cell, the stability of the outer membrane and surrounding organelles.

Norfloxacin is well absorbed from the gastrointestinal tract, its bioavailability is 30-40%. But simultaneous intake with food slows down absorption. Therefore, you need to take the medicine long before meals or an hour after. After one to two hours, a peak concentration of the drug is reached in the blood. The drug is withdrawn for a long time. The half-life takes about four hours, and in people with renal failure, the duration of the process can increase. The medicine is able to pass through the hematoplacental barrier and penetrate in small amounts into breast milk. Therefore, pregnant women and during breastfeeding are not prescribed. Large concentrations of norfloxacin are created in the tissues of the genitourinary tract, urine and bile. Up to 30% of the drug is excreted from the body with urine unchanged during the day. Another 30% enter the intestines and are excreted naturally.

In what cases is effective

The spectrum of antimicrobial activity of Norbactin is large. It is usually taken with the resistance of microorganisms to:

• penicillins;
• cephalosporins;
• aminoglycosides;
• tetracyclines.

Norbactin tablets are used against the following pathogens:

• E. coli;
• shigella;
• salmonella;
• campylobacter;
• cholera vibrio;
• gonococcus;
• pseudomonad;
• aeromonade;
• Proteus;
• serration;
• staphylococci of various types.

But the spectrum of activity does not apply to the following microorganisms:

• protozoa;
• viruses
• mushrooms;
• mycoplasmas;
• chlamydia
• pale spirochete.

Indications

The microorganisms listed above are not diseases in themselves, but cause an infectious process in various organs. Given the characteristics of the pharmacodynamics of the drug, indications for the use of Norbactin include the following diseases and conditions:

• urinary tract infections - cystitis, pyelonephritis, urethritis;
• genital diseases - prostatitis, cervicitisadnexitis endometritis;
• pathology of the digestive tract- diarrhea of ​​travelers, food poisoning;
• gonorrhea - uncomplicated form.

For the prevention of infectious complications, it is used in severe patients with granulocytopenia, a critically low level of some forms of white blood cells.

Who should not be assigned

The drug has a certain range of contraindications. They include the following conditions:

• individual hypersensitivity;
• age up to 18 years;
• pregnancy and lactation;
• severe renal failure.

There are indications that in patients who have recently had tendon ruptures, treatment with fluoroquinolone drugs is not recommended.

Side effects

It is also necessary to refuse treatment in case of side effects of Norbactin. They can manifest themselves on the part of various organs and systems:

• digestion - abdominal pain, diarrhea, nausea, vomiting, pseudomembranous colitis, increased activity of liver enzymes, hepatitis, pancreatitis;
• urinary organs- the appearance of crystals in the urine, glomerulonephritis, polyuria, protein in the urine, blood secretion;
• central nervous system - drowsiness, hallucinations, headache, fatigue, creeping sensation, depression, euphoria, polyneuropathy, epileptic seizures;
• heart and blood vessels- heart palpitations, arrhythmia, pressure drop;
• bones and joints - joint pain, inflammation and rupture of tendons, myalgia, arthritis;
• integumentary system - skin itching, photosensitivity, urticaria, Lyell syndrome, Stephen-Johnson.

If exceeded the dose

Symptoms of an overdose of the drug are accompanied by a violation of the function of the internal organs, which are most susceptible to the effects of the drug. The following symptoms appear:

• fever;
• severe allergic reaction;
• dyspnea;
• renal or liver failure;
• hemolytic anemia;
• digestive disorders.

Treatment includes gastric lavage, drinking plenty of fluids that are high in calcium (milk). The rest is symptomatic treatment to maintain body functions.

Instructions for use "Norbactin"

The treatment regimen "Norbactin" involves daily intake of tablets. They are drunk twice, dividing the dose in half, or once a day at the same time. It is correct to prescribe treatment after taking material for microbiological examination in order to determine the sensitivity spectrum of the pathogen. It is possible to apply Norbactin even before obtaining results from the laboratory, but with subsequent possible adjustment.
The dosage of the drug depends on the pathology. The main ones are collected in the table.

Table - Dosage "Norbactin"

Interaction with other substances

The use of alcohol during therapy with fluoroquinolones is completely eliminated. Even analogues of Norbactin ("Nolicin”,“ Normax ”) cause negative consequences in the form of severe depression of the nervous system up to the development of coma.

According to doctors and various studies, simultaneous administration with the following substances and medicines is not recommended:

• caffeine;
• calcium preparations;
• milk products;
• "Theophylline";
• Warfarin
• Cyclosporin;
• hormonal contraceptives;
• macrolides;
• antipsychotics.

Reviews on Norbactin tablets indicate high effectiveness in the treatment of genitourinary infections. But it should be remembered that during therapy, the body needs a sufficient amount of fluid to ensure the normal functioning of the kidneys and proper excretion of the medicine.

Reviews

For many years I had cystitis, which could not be cured by any medications that the doctors prescribed in the clinic. I had to go to an expensive paid hospital. And there I was recommended Norbactin. What is most interesting is a completely inexpensive drug, but, interestingly, it actually cured me.

Begel Natalia, https://www.piluli.ru/product/Norbaktin/review

I have chronic cystitis. Just freeze a little and painful urination and seizing pains begin. Who is sick, he will understand.
I didn’t hesitate for a long time - I went to the pharmacy, since I went to the doctor many times, prescribes the same drugs that the pharmacist will sell.
The pharmacist offered me not expensive, but very good, in her words, the drug. There are ten tablets in the package, you need to take from three to seven days. The tablets are not small, but are swallowed normally. They act mainly as an antimicrobial agent.

I came home - I immediately accepted, because I already had no strength to endure. On the second day of admission, my pain and frequent urge to the toilet almost completely disappeared. On the third day, I began to have severe headaches. Noise in the ears, pains in the head were girdle. Nausea appeared, sometimes a gag reflex was manifested. Painkillers did not help relieve headaches. This went on all the days that I drank pills.

When I finished the appointment, I did not immediately realize that the headaches stopped immediately, and the noise in my ears went away, and nausea. But only then it dawned on me that the tablets gave a side effect. The instructions for use say that there may be just all of these ailments. Of course, I understand that there may be a side effect, but not in such quantity. And also, I probably made a mistake at the pharmacy when I asked for an inexpensive drug. In general, I will refuse these pills forever and I do not advise you. No wonder it is advertised, apparently in need.

Anna10, http://otzovik.com/review_1415576.html

Norbactin acts quickly, almost immediately after the first pill it becomes easier, pain and urges disappear, but other problems appear. Personally, I have nausea, heartburn, and abdominal pain, and I'm sorry, upset stomach. Just as it is written in the list of side effects in the annotation (((Somehow I survived this, but honestly admit - with difficulty.

Gregory https://www.piluli.ru/product/Norbaktin/review

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