The content of the article
It was precisely as an antidepressant that the formula of sibutramine hydrochloride monohydrate salt was developed. Its synthesis was carried out by American scientists. During tests of the drug, it was found that taking it for its intended purpose is not practical - there are too many side effects and difficulties in combining with other medicines. In the process of research, an anorexigenic effect was observed for sibutramine - the ability to inhibit appetite at the level of the central nervous system, after which the drug was considered as a means for losing weight.
Breakthrough in Dietetics
At the moment, sibutramine in drugs is dosed at 10 and 15 mg. During drug testing, dosages were used that were significantly higher than current dosages. The result - losing weight was easy and fast. The patient’s appetite was almost completely lost, and fat depots were spent twice as active, because the energy needs of the body require constant satisfaction.
Sibutramine radar turned out to be effective against pathological excess weight when the body mass index went off scale at more than 30. Research could be called a real revolution in dietetics, if not for the side effects of the drug. The use of huge dosages was accompanied by multiple side effects, including:
- heart attacks and strokes;
- heart rhythm disturbances;
- lesions of the gastrointestinal mucosa;
- migraine pains;
- mental disorders.
Therefore, at that stage they could not launch the drug into mass use. Having found the minimum therapeutic doses, scientists achieved positive dynamics in reducing the incidence of side effects, which made it possible to register the drug as a medicine for the treatment of obesity.
Weight reduction mechanism
"Sibutramine" or its analogues is prescribed by nutritionists or psychiatrists to people with nutritional obesity and eating disorders. Often the appointment occurs if other ways to reduce weight have exhausted themselves. Sibutramine acts on the body as follows:
- blocks the capture of the neurotransmitter serotonin;
- blocks the capture of the neurotransmitter norepinephrine;
- to a much lesser extent inhibits dopamine uptake.
Violation of the consumption and transformation of mediators in the central nervous system leads to the development of similar mechanisms in all organs and tissues. The consequences of taking sibutramine are as follows:
- appetite- the patient’s feeling of hunger is significantly dulled, he may not experience it at all, even if there was not a single meal in a day;
- metabolism- due to the effect on vascular tone, heat transfer increases, the body is forced to consume more energy, using its reserves from the depot;
- fat burning- based on the previous effect, since the flow of energy from the outside is significantly reduced;
- saturation - due to dulling of appetite, the patient has a feeling of fullness almost immediately after the start of the meal;
- digestion- noticeably improves due to increased serotonin concentration in the mucous membranes of the gastrointestinal tract (GIT), peristalsis and juice production improves;
- mood- improves due to an increase in the level of “hormones of happiness”, the patient feels happy even in case of food dependence;
- activity- increases due to increased excitability of the central nervous system, the patient feels a surge of strength, vigor, ready for action throughout the day.
A number of changes in the brain that are provoked by the use of sibutramine facilitate weight loss at all levels: physical, emotional, hormonal. A feature of the drug is its ability to intensify the burning of “brown fat”. Although these accumulations are contained in small quantities in the human body, they play a crucial role in the process of thermoregulation. And their splitting activates the consumption of "white fat", an excess of which accompanies obesity.
Instructions for use of sibutramine
Sibutramine belongs to the group of overweight remedies intended “as a last resort”. The reception of funds must necessarily be agreed with the doctor to make sure that all available methods of correcting body weight are exhausted. This approach is necessary because of the huge health risk that is fraught with interference in the functioning of the nervous system.
Often, intake begins with a minimum dose of 10 mg. A tablet of the appropriate dosage is taken once for knocking down with a sufficient amount of liquid. Taking the drug does not depend on the time of the meal, but doctors recommend drinking the tablets in the morning on an empty stomach after waking up to ensure maximum concentrations of the drug in the blood in the morning.
The action develops as follows:
- 80% of the contents of the tablet - absorbed in the small intestine;
- active metabolites of sibutramine - released into the blood and bind to its proteins;
- blood concentration reaches a maximum - three to four hours after administration;
- drug metabolites - are carried throughout the body, accumulating in synaptic joints;
- after taking the fourth pill - A stable therapeutic concentration of the drug is achieved in the tissues.
Reception is undesirable to combine with food. The fact is that the absorption of the drug from the food lump is worse - it decreases by a third. The substance is excreted from the body by the kidneys. Fragments of metabolites are in the tissues for about a month, but their concentration after the end of administration does not carry therapeutic significance.
Sibutramin diet pills could be taken up to a year. Now they also drink analogues. If the minimum dosage of 10 mg is satisfactory, it remains until the end of the course of treatment.The need for an increase in dosage arises if, within two to three months after the start of the intake, the “plumb” of the patient amounted to 3% of the total body weight. Then prescribed sibutramine in a dose of 15 mg. In the event that the plumb line remains minimal, the drug is canceled due to inefficiency. All decisions regarding the dosage, as well as the timing of treatment, are made by the doctor.
Harm Facts
Given the comprehensive assistance of the drug in the process of losing weight, the question arises: "What will I have to pay for such tangible support on the path to harmony?" The answer lies in the results of studies of the substance, which clearly list its side effects. But focusing on the reviews of losing weight, we can say that the drug is often tolerated. Some undesirable effects that occur at the beginning of therapy lose intensity or disappear altogether if sibutramine is taken correctly. The most common side effects:
- a feeling of dry mouth;
- violation of the stool;
- exacerbation of hemorrhoids;
- headaches;
- heart palpitations;
- insomnia;
- complete lack of appetite;
- slight increase in blood pressure.
Side effects of sibutramine, as with other drugs, include the possibility of an allergic reaction, manifested by urticaria and pruritus. In this case, the drug is canceled.
More serious adverse effects of the drug include addiction and withdrawal. Drug dependence does not occur, however, the first time after discontinuation of treatment, the patient's psycho-emotional state may worsen, which can provoke a return to old eating habits. To reduce the intensity of these effects, doctors recommend stopping treatment, gradually reducing the dosage of the drug.
Dangerous unwanted effects include:
- psychological disorders (up to suicidal mood);
- eating disorders (bulimia, anorexia);
- increased risk of heart attacks;
- insomnia
- critical increase in blood pressure;
- tachycardia;
- fainting
- impaired peripheral circulation.
To whom the funds are prohibited
Sibutramine-based drugs have an impressive list of serious contraindications. The main ones are violations in the work of the heart, liver and kidneys, since the substance creates the main load on these organs.
The damage to the drug is more significant if obesity is not of alimentary origin, but is secondary. Most often, metabolic disorders and the work of internal organs lead to it. Medical practice confirms the inefficiency of sibutramine in such situations. Other contraindications for taking the drug:
- up to 18 years old;
- after 65 years;
- with bulimia;
- with anorexia;
- mental disorders;
- teak;
- hyperthyroidism;
- arterial hypertension;
- BPH;
- glaucoma;
- substance abuse;
- drug dependence;
- alcoholism.
Particular care requires the appointment of sibutramine to epileptics and people prone to seizures, as well as those with impaired hematopoiesis or blood clotting.
Treatment before, during and after pregnancy
Sometimes obesity is a cause of hormonal imbalance in women, it prevents the pregnancy, pregnancy and the birth of a healthy baby. The situation requires nutritional and medical intervention.If other methods of weight correction are ineffective, sibutramine can be prescribed before pregnancy. It is important to consider that the drug has a teratogenic effect, that is, it can provoke anomalies in the development of the fetus.
For the entire period of treatment, a woman should provide reliable contraception. From the end of the course of treatment to the moment of conception, at least two months should pass. During this period, the body will get rid of the remnants of the drug substance. Treatment with the drug during pregnancy and breastfeeding is strictly prohibited.
Analogs
The full analogues of Sibutramin are drugs:
They contain sibutramine hydrochloride monohydrate salt, are available in two dosages, like the original drug.
Advanced forms of sibutramine are Goldline Plus and Reduxine Met. In addition to the active substance, microcrystalline cellulose is included in their composition, which supports the anorexigenic effect of sibutramine. Reduxin Met also includes metformin, a stimulant of the sensitivity of body cells to insulin.
All analog drugs are dangerous in the same way that sibutramine is dangerous, have the same contraindications and side effects. Goldline Light dietary supplement does not contain sibutramine, and therefore can not be compared with the original drug.
Reviews about the Sibutramin drug pills are very diverse. Some people have successfully lost weight, completely rebuilt their diet and eating habits, without feeling anything more uncomfortable than dry mouth. In other cases, the drug ended for patients with long-term treatment of psychological disorders. One way or another, sibutramine therapy implies strict medical supervision. With independent use of the drug, the risk of serious consequences increases.
Reviews: “The effect was short-lived”
She took Reduxin 10 mg for 3 months and was very pleased with the result. Weight was 78 kg with a height of 152 cm, on the "Reduxine" lost weight to 61 kg. Of course, the first 2 weeks were a little uncomfortable - thirst and insomnia were annoying, but the sea increased energy, productivity at work increased significantly (I work as a teacher). Among the unexpected positive effects, I can note the disappearance of symptoms menopause (hot flashes, heavy sweat) and normalization of blood sugar. If you compare with the similar drug "Goldline", I will give preference to "Reduxin" - and the side effect is softer and the result is better. Of course, it’s better to take it under the supervision of a doctor, I consulted with a local therapist.
Irina S., https://protabletky.ru/reduxin/#otzivi
I took these capsules to lose weight. I bought it myself, I decided to drink it myself. For which I really reproach myself. Yes, I lost weight on it, and dramatically by 11 kilograms. But the effect was short-lived. Literally after 4 months, everything returned. I lost 11, and returned 19 kilograms. The appetite from these capsules drops immediately, I do not want to eat at all. Eat became much less, drank a lot of water. But this did not save me from the onset of migraines, tachycardia, constipation. The head ached constantly, and even insomnia every night. Keep in mind, for this drug there are a huge number of contraindications, and I personally experienced most of the side effects. And in addition, after the end of the intake, all my kilograms returned to me. The price of the drug is expensive, it’s better to go to the gym for the money. I can summarize that I regret taking these capsules. I do not recommend them to anyone.
Olga T., https://protabletky.ru/reduxin/#otzivi
Loading...